Agitation associated with schizophrenia and bipolar disorder can create dangerous situations for patients and caregivers and is one of the leading contributors of direct medical costs, including emergency department visits and hospitalizations.
The differential diagnosis of agitation that accompanies schizophrenia or bipolar disorder can only be determined after a careful evaluation of the patient and consideration of all factors that may be contributing to an agitated state.
Patients with schizophrenia or bipolar mania can preĀ­sent with agitation. The behavioral manifestations of agitation are similar for both disease states and are measured in research protocols using the same scales.
Differentiating between schizophrenia and bipolar disorder has been one of the most difficult tasks in the diagnosis of mental disorders. There are several reasons for this, including the overlap of symptoms of agitation between schizophrenia and the manic episodes of bipolar disorder.

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